Reaction Details Report a problem with these data
Target
Arginase-2, mitochondrial
Ligand
BDBM50462600
Substrate
n/a
Meas. Tech.
ChEMBL_1775776 (CHEMBL4232768)
Ki
437000±n/a nM
Citation
 Guo, X; Chen, Y; Seto, CT Rational design of novel irreversible inhibitors for human arginase. Bioorg Med Chem 26:3939-3946 (2018) [PubMed]  Article 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM50462600
Synonyms:
CHEMBL4238387
Type:
Small organic molecule
Emp. Form.:
C11H13N3O4
Mol. Mass.:
251.2386
SMILES:
CC(=O)OC(C(O)=O)c1ccc(NC(N)=N)cc1
Structure:
Search PDB for entries with ligand similarity: