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Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Ligand
BDBM50463171
Substrate
n/a
Meas. Tech.
ChEMBL_1777818 (CHEMBL4234810)
IC50
13100±n/a nM
Citation
 Nigam, R; Babu, KR; Ghosh, T; Kumari, B; Akula, D; Rath, SN; Das, P; Anindya, R; Khan, FA Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3. Bioorg Med Chem 26:4100-4112 (2018) [PubMed]  Article 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Synonyms:
ABH3 | ALKB3_HUMAN | ALKBH3 | Alkylated DNA repair protein alkB homolog 3 | DEPC-1 | DEPC1 | Prostate cancer antigen 1
Type:
PROTEIN
Mol. Mass.:
33382.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108024
Residue:
286
Sequence:
MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
  
Inhibitor
Name:
BDBM50463171
Synonyms:
CHEMBL4242283
Type:
Small organic molecule
Emp. Form.:
C30H24O3
Mol. Mass.:
432.5098
SMILES:
COc1cccc(c1)C1=C(c2cc(ccc2C1=O)-c1ccc(C)cc1)c1cccc(OC)c1 |t:9|
Structure:
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