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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50043799
Substrate
n/a
Meas. Tech.
ChEMBL_1777837 (CHEMBL4234829)
IC50
380000±n/a nM
Citation
 Chien, HC; Colas, C; Finke, K; Springer, S; Stoner, L; Zur, AA; Venteicher, B; Campbell, J; Hall, C; Flint, A; Augustyn, E; Hernandez, C; Heeren, N; Hansen, L; Anthony, A; Bauer, J; Fotiadis, D; Schlessinger, A; Giacomini, KM; Thomas, AA Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem 61:7358-7373 (2018) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | Large neutral amino acids transporter small subunit 1 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter | LAT1_HUMAN | SLC7A5 | CD98LC | LAT1 | MPE16
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Human
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50043799
Synonyms:
(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid | (R)-tryptophan | D-TRYPTOPHAN | CHEMBL292303
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: