Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type II subunit beta
Ligand
BDBM50463484
Substrate
n/a
Meas. Tech.
ChEMBL_1778335 (CHEMBL4235327)
Ki
>2000±n/a nM
Citation
 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors. Bioorg Med Chem Lett 28:2622-2626 (2018) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit beta
Synonyms:
Calcium/calmodulin-dependent protein kinase type II | Calcium/calmodulin-dependent protein kinase type II beta chain | CaM kinase II | CaM kinase II beta | CaMK-II subunit beta | CaM kinase II subunit beta | CaM-kinase II beta chain | KCC2B_HUMAN | CAMK2B | CAM2 | CAMK2 | CAMKB
Type:
Enzyme Catalytic Domain
Mol. Mass.:
72685.48
Organism:
Human
Description:
gi_26051204
Residue:
666
Sequence:
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
  
Inhibitor
Name:
BDBM50463484
Synonyms:
CHEMBL4248525
Type:
Small organic molecule
Emp. Form.:
C26H30N6O2S
Mol. Mass.:
490.63
SMILES:
CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(cs3)-c3c[nH]c4ncccc34)c2)CC1
Structure:
Search PDB for entries with ligand similarity: