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Target
3-oxoacyl-ACP synthase
Ligand
BDBM23570
Substrate
n/a
Meas. Tech.
ChEMBL_1788585 (CHEMBL4260319)
IC50
65000±n/a nM
Citation
 Soukarieh, F; Williams, P; Stocks, MJ; Cámara, M Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives. J Med Chem 61:10385-10402 (2018) [PubMed]  Article 
Target
Name:
3-oxoacyl-ACP synthase
Synonyms:
PQB biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase III | YQ19_24710 | pqsD | 2-heptyl-4(1H)-quinolone synthase PqsD | 3-oxoacyl-(Acyl carrier protein) synthase III | 3-oxoacyl-ACP synthase | ERS445055_04170 | PA8380_44470 | PAE221_04722
Type:
PROTEIN
Mol. Mass.:
36357.84
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_109728
Residue:
337
Sequence:
MGNPILAGLGFSLPKRQVSNHDLVGRINTSDEFIVERTGVRTRYHVEPEQAVSALMVPAARQAIEAAGLLPEDIDLLLVNTLSPDHHDPSQACLIQPLLGLRHIPVLDIRAQCSGLLYGLQMARGQILAGLARHVLVVCGEVLSKRMDCSDRGRNLSILLGDGAGAVVVSAGESLDDGLLDLRLGADGNYFDLLMTAAPGSASPTFLDENVLREGGGEFLMRGRPMFEHASQTLVRIAGEMLAAHELTLDDIDHVICHQPNLRILDAVQEQLGIPQHKFAVTVDRLGNMASASTPVTLAMFWPDIQPGQRVLVLTYGSGATWGAALYRKPEEVNRPC
  
Inhibitor
Name:
BDBM23570
Synonyms:
2-{[4-bromo-3-(diethylsulfamoyl)benzene]amido}benzoic acid | Diethylsulfonamide Derivative, 13a
Type:
Small organic molecule
Emp. Form.:
C18H19BrN2O5S
Mol. Mass.:
454.02
SMILES:
CCN(CC)S(=O)(=O)c1cc(ccc1Br)C(=O)Nc2ccccc2C(=O)O
Structure:
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