Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50023050
Substrate
n/a
Meas. Tech.
ChEMBL_196261 (CHEMBL803238)
Ki
4.8±n/a nM
Citation
 Evans, BE; Rittle, KE; Bock, MG; Bennett, CD; DiPardo, RM; Boger, J; Poe, M; Ulm, EH; LaMont, BI; Blaine, EH A uniquely potent renin inhibitor and its unanticipated plasma binding component. J Med Chem 28:1755-6 (1986) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | RENI_HUMAN | REN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Human
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50023050
Synonyms:
{1-[1-(1-{2-[1-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-1-hydroxy-ethyl}-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | CHEMBL40928
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: