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Target
Melatonin receptor type 1A/1B
Ligand
BDBM50066960
Substrate
n/a
Meas. Tech.
ChEMBL_104780 (CHEMBL874168)
IC50
26±n/a nM
Citation
 Mor, M; Rivara, S; Silva, C; Bordi, F; Plazzi, PV; Spadoni, G; Diamantini, G; Balsamini, C; Tarzia, G; Fraschini, F; Lucini, V; Nonno, R; Stankov, BM Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. J Med Chem 41:3831-44 (1998) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A/1B
Synonyms:
Melatonin receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 104946
Components:
This complex has 2 components.
Component 1
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A protein | Mel-1A-R | Melatonin receptor type 1A | Mel1a melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin 1A | MTR1A_HUMAN | MTNR1A | Melatonin receptor
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Human
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Component 2
Name:
Melatonin receptor type 1B
Synonyms:
Mel-1B-R | Mel1b melatonin receptor | Melatonin receptor | Melatonin receptor type 1B | Melatonin 1B | Melatonin receptor type 2 (MT2) | MTR1B_HUMAN | MTNR1B
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Human
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50066960
Synonyms:
N-[2-(5-Methoxy-1-methyl-1H-indol-3-yl)-ethyl]-acetamide | N-(2-(5-methoxy-1-methyl-1H-indol-3-yl)ethyl)acetamide | CHEMBL33700
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc2n(C)cc(CCNC(C)=O)c2c1
Structure:
Search PDB for entries with ligand similarity: