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Target
Carbonic anhydrase 4
Ligand
BDBM11392
Substrate
n/a
Meas. Tech.
ChEMBL_45436 (CHEMBL657036)
IC50
128±n/a nM
Citation
 Kim, CY; Whittington, DA; Chang, JS; Liao, J; May, JA; Christianson, DW Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. J Med Chem 45:888-93 (2002) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) | CA-IV | Carbonate dehydratase IV | CAH4_HUMAN | CA4 | Carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Human
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM11392
Synonyms:
(4R)-4-amino-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide | AL-8520
Type:
Small organic molecule
Emp. Form.:
C10H17N3O5S3
Mol. Mass.:
355.03
SMILES:
COCCCN1C[C@H](N)c2cc(sc2S1(=O)=O)S(N)(=O)=O |r|
Structure:
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