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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM8732
Substrate
n/a
Meas. Tech.
ChEMBL_597851 (CHEMBL1039114)
IC50
50±n/a nM
Citation
 Sampson, PB; Picard, C; Handerson, S; McGrath, TE; Domagala, M; Leeson, A; Romanov, V; Awrey, DE; Thambipillai, D; Bardouniotis, E; Kaplan, N; Berman, JM; Pauls, HW Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI). Bioorg Med Chem Lett 19:5355-8 (2009) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | NADPH-dependent enoyl-ACP reductase | trans-2-enoyl-[acyl carrier protein] reductase | FABI_STAAR | fabI | Enoyl-ACP Reductase (FabI)
Type:
Enzyme
Mol. Mass.:
27989.00
Organism:
Staphylococcus aureus (strain MRSA252)
Description:
Q6GI75
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM8732
Synonyms:
(2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide | (E)-N-Methyl-N-(1-methyl-1H-indol-2-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | indole naphthyridinone 21
Type:
Small organic molecule
Emp. Form.:
C22H22N4O2
Mol. Mass.:
374.17
SMILES:
CN(Cc1cc2ccccc2n1C)C(=O)\C=C\c1cnc2NC(=O)CCc2c1
Structure:
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