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Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50235738
Substrate
n/a
Meas. Tech.
ChEMBL_653215 (CHEMBL1226418)
IC50
400±n/a nM
Citation
 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol 2:213-20 (2006) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | eIF-4A-I | eIF4A-I | IF4A1_HUMAN | EIF4A1 | DDX2A | EIF4A
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Human
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50235738
Synonyms:
Hippuristanol
Type:
Small organic molecule
Emp. Form.:
C28H46O5
Mol. Mass.:
462.33
SMILES:
C[C@H]1C[C@]2([C@]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(C[C@@H]([C@H]5[C@H]4CC[C@@H]6[C@@]5(CC[C@H](C6)O)C)O)C)(C)O)OC1(C)C
Structure:
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