Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50483195
Substrate
n/a
Meas. Tech.
ChEMBL_690866 (CHEMBL1634228)
IC50
10000±n/a nM
Citation
Nakayama, J; Uemura, Y; Nishiguchi, K; Yoshimura, N; Igarashi, Y; Sonomoto, K Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria. Antimicrob Agents Chemother 53:580-6 (2009) [PubMed] Article More Info.:
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a1 | Cyp11a | Cyp11a-1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rat
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
Inhibitor
Name:
BDBM50483195
Synonyms:
Ambuic Acid
Type:
Small organic molecule
Emp. Form.:
C19H26O6
Mol. Mass.:
350.41
SMILES:
[H][C@]12O[C@@]1(C\C=C(/C)C(O)=O)C(=O)C(\C=C\CCCCC)=C(CO)[C@@H]2O |r,t:21|
Structure:
