Reaction Details Report a problem with these data
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50074960
Substrate
n/a
Meas. Tech.
ChEMBL_809999 (CHEMBL2015108)
Ki
50±n/a nM
Citation
Warmus, JS; Quinn, CL; Taylor, C; Murphy, ST; Johnson, TA; Limberakis, C; Ortwine, D; Bronstein, J; Pagano, P; Knafels, JD; Lightle, S; Mochalkin, I; Brideau, R; Podoll, T Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC. Bioorg Med Chem Lett 22:2536-43 (2012) [PubMed] Article
More Info.:
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
Inhibitor
Name:
BDBM50074960
Synonyms:
(R)-2-(3,4-Dimethoxy-5-propyl-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid hydroxyamide | (R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | CHEMBL107313 | L-161240
Type:
Small organic molecule
Emp. Form.:
C15H20N2O5
Mol. Mass.:
308.3297
SMILES:
CCCc1cc(cc(OC)c1OC)C1=N[C@H](CO1)C(=O)NO |t:14|