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Target
Reverse transcriptase
Ligand
BDBM50105463
Substrate
n/a
Meas. Tech.
ChEMBL_856669 (CHEMBL2162206)
IC50
2000±n/a nM
Citation
 Jain, N; Francis, S; Friedman, SH Inhibition of therapeutically important polymerases with high affinity bis-intercalators. Bioorg Med Chem Lett 22:4844-8 (2012) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus type 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50105463
Synonyms:
3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide | 2,7-diamino-10-ethyl-9-phenylphenanthridinium bromide | 2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide | Dromilac | EtBr | Ethidium bromide | Homidium bromide | CHEMBL284328
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCn1c(-c2ccccc2)c2cc(N)ccc2c2ccc(=[NH2+])cc12
Structure:
Search PDB for entries with ligand similarity: