Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50038263
Substrate
n/a
Meas. Tech.
ChEMBL_54271 (CHEMBL669266)
Kd
5800±n/a nM
Citation
 Ivery, MT; Gready, JE Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase. J Med Chem 37:4211-21 (1995) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase | DYR_HUMAN | DHFR
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Human
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50038263
Synonyms:
2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one | CHEMBL135811
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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