Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50038261
Substrate
n/a
Meas. Tech.
ChEMBL_53628 (CHEMBL666657)
Kd
2400±n/a nM
Citation
 Ivery, MT; Gready, JE Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase. J Med Chem 37:4211-21 (1995) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DYR_CHICK | DHFR
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Chicken
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50038261
Synonyms:
2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one | CHEMBL340269
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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