Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50038273
Substrate
n/a
Meas. Tech.
ChEMBL_53621 (CHEMBL663690)
pH
6.6000±n/a
Kd
11000±n/a nM
Comments
extracted
Citation
 Ivery, MT; Gready, JE Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase. J Med Chem 37:4211-21 (1995) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase | DYR_HUMAN | DHFR
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Human
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50038273
Synonyms:
2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one | CHEMBL341200
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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