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Target
Estrogen receptor beta
Ligand
BDBM50494961
Substrate
n/a
Meas. Tech.
ChEMBL_1282733 (CHEMBL3102030)
IC50
108±n/a nM
Citation
 McCullough, C; Neumann, TS; Gone, JR; He, Z; Herrild, C; Wondergem Nee Lukesh, J; Pandey, RK; Donaldson, WA; Sem, DS Probing the human estrogen receptor-α binding requirements for phenolic mono- and di-hydroxyl compounds: a combined synthesis, binding and docking study. Bioorg Med Chem 22:303-10 (2014) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
Estrogen receptor | ER-beta | Estrogen receptor beta (ER beta) | Nuclear receptor subfamily 3 group A member 2 | estrogen beta | Estrogen receptor (ER beta) | Estrogen receptor beta (ER) | Estrogen receptor beta | ESR2_HUMAN | ESR2 | ESTRB | NR3A2 | Estradiol receptor beta (ERβ)
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Human
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50494961
Synonyms:
CHEMBL3099428 | US10570077, Compound 11
Type:
Small organic molecule
Emp. Form.:
C22H30O2
Mol. Mass.:
326.48
SMILES:
[H][C@@]12CC=C([C@@H](C)CCO)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H] |r,t:3|
Structure:
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