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Target
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ligand
BDBM50031533
Substrate
n/a
Meas. Tech.
ChEMBL_1335026 (CHEMBL3239457)
Kd
29000±n/a nM
Citation
 Yun, MK; Hoagland, D; Kumar, G; Waddell, MB; Rock, CO; Lee, RE; White, SW The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg Med Chem 22:2157-65 (2014) [PubMed]  Article 
Target
Name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Synonyms:
JW0138 | PPPK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase | HPPK | HPPK_ECOLI | folK
Type:
PROTEIN
Mol. Mass.:
18075.55
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_108237
Residue:
159
Sequence:
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
  
Inhibitor
Name:
BDBM50031533
Synonyms:
CHEMBL3233202
Type:
Small organic molecule
Emp. Form.:
C13H10N6OS
Mol. Mass.:
298.06
SMILES:
Nc1nc2nc(SCc3ccc(cc3)C#N)[nH]c2c(=O)[nH]1
Structure:
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