Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50497251
Substrate
n/a
Meas. Tech.
ChEMBL_1459831 (CHEMBL3371217)
IC50
13±n/a nM
Citation
 Myslinski, JM; Clements, JH; Martin, SF Protein-ligand interactions: probing the energetics of a putative cation-? interaction. Bioorg Med Chem Lett 24:3164-7 (2014) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50497251
Synonyms:
CHEMBL3360189
Type:
Small organic molecule
Emp. Form.:
C30H36N6O14P2
Mol. Mass.:
766.5862
SMILES:
C[C@](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)OCc1cccc(N)c1)(C(=O)N[C@@H](CC(N)=O)C(N)=O)c1ccc(OP(O)(O)=O)cc1 |r|
Structure:
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