Reaction Details Report a problem with these data
Target
Retinoic acid receptor beta
Ligand
BDBM50045278
Substrate
n/a
Meas. Tech.
ChEMBL_163490 (CHEMBL772402)
EC50
1100±n/a nM
Citation
 Jong, L; Lehmann, JM; Hobbs, PD; Harlev, E; Huffman, JC; Pfahl, M; Dawson, MI Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity. J Med Chem 36:2605-13 (1993) [PubMed]  Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50498.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458015
Residue:
455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
  
Inhibitor
Name:
BDBM50045278
Synonyms:
4-[(E)-2-(1,2,3,4-Tetrahydro-1,4-methano-naphthalen-6-yl)-propenyl]-benzoic acid | 4-[2-(1,2,3,4-Tetrahydro-1,4-methano-naphthalen-6-yl)-propenyl]-benzoic acid | CHEMBL40007
Type:
Small organic molecule
Emp. Form.:
C21H20O2
Mol. Mass.:
304.3823
SMILES:
C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2C3CCC(C3)c2c1
Structure:
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