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Target
Carnitine O-palmitoyltransferase 1, liver isoform
Ligand
BDBM50046145
Substrate
n/a
Meas. Tech.
ChEBML_46327
Ki
4200±n/a nM
Citation
 Gandour, RD; Leung, OT; Greway, AT; Ramsay, RR; Nic a'Bháird, N; Fronczek, FR; Bellard, BM; Kumaravel, G (+)-Hemipalmitoylcarnitinium strongly inhibits carnitine palmitoyltransferase-I in intact mitochondria. J Med Chem 36:237-42 (1993) [PubMed]  Article 
Target
Name:
Carnitine O-palmitoyltransferase 1, liver isoform
Synonyms:
CPT I | CPT1-L | CPTI-L | Carnitine O-palmitoyltransferase I, liver isoform | CPT1A_RAT | Cpt1a | Cpt-1 | Cpt1 | Carnitine palmitoyltransferase 1A
Type:
PROTEIN
Mol. Mass.:
88147.11
Organism:
Rat
Description:
ChEMBL_887445
Residue:
773
Sequence:
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTKNIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKSTAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTINSKK
  
Inhibitor
Name:
BDBM50046145
Synonyms:
2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4-oxazinan-4-ium-2-yl]acetate(hemipalmitoylcarnitinium (HPC)) | Acylcarnitine analogue | Hemiacylcarnitinium(+)-HPC | CHEMBL48257
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCCCCCCCCCCCCCC[C@@]1(O)C[N+](C)(C)C[C@@H](CC([O-])=O)O1
Structure:
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