Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50051553
Substrate
n/a
Meas. Tech.
ChEMBL_196002 (CHEMBL797866)
Kd
1.3±n/a nM
Citation
 Yu, KL; Spinazze, P; Ostrowski, J; Currier, SJ; Pack, EJ; Hammer, L; Roalsvig, T; Honeyman, JA; Tortolani, DR; Reczek, PR; Mansuri, MM; Starrett, JE Retinoic acid receptor beta,gamma-selective ligands: synthesis and biological activity of 6-substituted 2-naphthoic acid retinoids. J Med Chem 39:2411-21 (1996) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50051553
Synonyms:
6-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-naphthalene-2-carboxylic acid | CHEMBL82716
Type:
Small organic molecule
Emp. Form.:
C27H28O2
Mol. Mass.:
384.51
SMILES:
CC1(C)CCC(C)(C)c2cc(ccc12)C(=C)c1ccc2cc(ccc2c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: