Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50051556
Substrate
n/a
Meas. Tech.
ChEMBL_197404 (CHEMBL799794)
Kd
6500±n/a nM
Citation
 Yu, KL; Spinazze, P; Ostrowski, J; Currier, SJ; Pack, EJ; Hammer, L; Roalsvig, T; Honeyman, JA; Tortolani, DR; Reczek, PR; Mansuri, MM; Starrett, JE Retinoic acid receptor beta,gamma-selective ligands: synthesis and biological activity of 6-substituted 2-naphthoic acid retinoids. J Med Chem 39:2411-21 (1996) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50051556
Synonyms:
6-[Methoxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-naphthalene-2-carboxylic acid | CHEMBL78835
Type:
Small organic molecule
Emp. Form.:
C27H30O3
Mol. Mass.:
402.5253
SMILES:
COC(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc2cc(ccc2c1)C(O)=O
Structure:
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