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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50052957
Substrate
n/a
Meas. Tech.
ChEMBL_196780 (CHEMBL799565)
EC50
2800±n/a nM
Citation
 Beard, RL; Colon, DF; Song, TK; Davies, PJ; Kochhar, DM; Chandraratna, RA Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid. J Med Chem 39:3556-63 (1996) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50052957
Synonyms:
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-sulfonyl)-benzoic acid | CHEMBL118307
Type:
Small organic molecule
Emp. Form.:
C22H26O4S
Mol. Mass.:
386.504
SMILES:
Cc1cc2c(cc1S(=O)(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Structure:
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