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Target
Folate receptor beta
Ligand
BDBM50503240
Substrate
n/a
Meas. Tech.
ChEMBL_1809830 (CHEMBL4309290)
IC50
3.1±n/a nM
Citation
 Ravindra, M; Wilson, MR; Tong, N; O'Connor, C; Karim, M; Polin, L; Wallace-Povirk, A; White, K; Kushner, J; Hou, Z; Matherly, LH; Gangjee, A Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem 61:4228-4248 (2018) [PubMed]  Article 
Target
Name:
Folate receptor beta
Synonyms:
FBP | FR-beta | Folate receptor 2 | Folate receptor beta | Folate receptor, fetal/placental | Placental folate-binding protein | FOLR2_HUMAN | FOLR2
Type:
PROTEIN
Mol. Mass.:
29286.32
Organism:
Human
Description:
ChEMBL_20077
Residue:
255
Sequence:
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
  
Inhibitor
Name:
BDBM50503240
Synonyms:
CHEMBL4445651
Type:
Small organic molecule
Emp. Form.:
C19H20FN5O6S
Mol. Mass.:
465.46
SMILES:
Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(O)=O)C(O)=O)c3F)cc2c(=O)[nH]1 |r|
Structure:
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