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Target
Folate receptor alpha
Ligand
BDBM50457435
Substrate
n/a
Meas. Tech.
ChEMBL_1809825 (CHEMBL4309285)
IC50
1.3±n/a nM
Citation
 Ravindra, M; Wilson, MR; Tong, N; O'Connor, C; Karim, M; Polin, L; Wallace-Povirk, A; White, K; Kushner, J; Hou, Z; Matherly, LH; Gangjee, A Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem 61:4228-4248 (2018) [PubMed]  Article 
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18 | FOLR1_HUMAN | FOLR1 | FOLR
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Human
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
  
Inhibitor
Name:
BDBM50457435
Synonyms:
CHEMBL4214638
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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