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Target
Proteasome subunit beta type-5
Ligand
BDBM50069985
Substrate
n/a
Meas. Tech.
ChEMBL_1812368 (CHEMBL4311828)
IC50
1.2±n/a nM
Citation
 Pehere, AD; Nguyen, S; Garlick, SK; Wilson, DW; Hudson, I; Sykes, MJ; Morton, JD; Abell, AD Tripeptide analogues of MG132 as protease inhibitors. Bioorg Med Chem 27:436-441 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
Proteasome Macropain subunit MB1 | 26S proteosome | PSB5_HUMAN | PSMB5 | LMPX | MB1 | X | Proteasome subunit beta type-1/beta type-5 | 20S proteasome chymotrypsin-like
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Human
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50069985
Synonyms:
{1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | benzyloxycarbonyl-Leu-Leu-leucinal | benzyl(S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate | Z-Leu-Leu-Leu-H | {1-[1-(1-Formyl-3-methyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Z-L-leu-L-leu-L-leu-H | benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate | Z-Leu-Leu-Leu-al | Cbz-L-leu-L-leu-L-leu-CHO | {(S)-1-[(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | MG-132 | (S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic acid [(S)-1-((S)-1-formyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-amide | CHEMBL64925 | MG-13
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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