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Target
Target of rapamycin complex 2 subunit MAPKAP1
Ligand
BDBM50505423
Substrate
n/a
Meas. Tech.
ChEMBL_1822731 (CHEMBL4322495)
IC50
207±n/a nM
Citation
 Borsari, C; Rageot, D; Dall'Asen, A; Bohnacker, T; Melone, A; Sele, AM; Jackson, E; Langlois, JB; Beaufils, F; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. J Med Chem 62:8609-8630 (2019) [PubMed]  Article 
Target
Name:
Target of rapamycin complex 2 subunit MAPKAP1
Synonyms:
Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1 | SIN1_HUMAN | MAPKAP1 | MIP1 | SIN1
Type:
PROTEIN
Mol. Mass.:
59129.70
Organism:
Human
Description:
ChEMBL_119716
Residue:
522
Sequence:
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
  
Inhibitor
Name:
BDBM50505423
Synonyms:
CHEMBL4458687
Type:
Small organic molecule
Emp. Form.:
C20H24N6O2
Mol. Mass.:
380.45
SMILES:
[H][C@]12Cc3c(nc(nc3N3CC4CCC(C3)O4)-c3ccc(N)nc3)N1CCOC2 |r|
Structure:
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