Reaction Details Report a problem with these data
Target
Target of rapamycin complex subunit LST8
Ligand
BDBM228153
Substrate
n/a
Meas. Tech.
ChEMBL_1822732 (CHEMBL4322496)
IC50
751±n/a nM
Citation
 Borsari, C; Rageot, D; Dall'Asen, A; Bohnacker, T; Melone, A; Sele, AM; Jackson, E; Langlois, JB; Beaufils, F; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. J Med Chem 62:8609-8630 (2019) [PubMed]  Article 
Target
Name:
Target of rapamycin complex subunit LST8
Synonyms:
G protein beta subunit-like | Gable | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8 | LST8_HUMAN | MLST8 | GBL | LST8
Type:
PROTEIN
Mol. Mass.:
35871.25
Organism:
Human
Description:
ChEMBL_118692
Residue:
326
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
  
Inhibitor
Name:
BDBM228153
Synonyms:
(S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazin-2- yl)-4-(trifluoromethyl)pyridin-2-amine | US9556203, 22
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Nc1cc(c(cn1)-c1nc2N3CCOC[C@@H]3Cc2c(n1)N1CCOCC1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: