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Target
Phosphatidylinositol 4-kinase beta
Ligand
BDBM50505407
Substrate
n/a
Meas. Tech.
ChEMBL_1822744 (CHEMBL4322508)
Kd
>30000±n/a nM
Citation
 Borsari, C; Rageot, D; Dall'Asen, A; Bohnacker, T; Melone, A; Sele, AM; Jackson, E; Langlois, JB; Beaufils, F; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. J Med Chem 62:8609-8630 (2019) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-kinase beta
Synonyms:
PI4-kinase beta subunit | Phosphatidylinositol 4-kinase, PI4K | PI4K-beta | PI4Kbeta | PtdIns 4-kinase beta | NPIK | PI4K92 | PIK4B | PI4KB_HUMAN | PI4KB | PIK4CB | Phosphatidylinositol 4-kinase beta
Type:
Protein
Mol. Mass.:
91373.30
Organism:
Human
Description:
n/a
Residue:
816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
  
Inhibitor
Name:
BDBM50505407
Synonyms:
CHEMBL4436124
Type:
Small organic molecule
Emp. Form.:
C18H23N7O2
Mol. Mass.:
369.43
SMILES:
[H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)nc3)N1CCOC2 |r|
Structure:
Search PDB for entries with ligand similarity: