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Target
Target of rapamycin complex subunit LST8
Ligand
BDBM50505421
Substrate
n/a
Meas. Tech.
ChEMBL_1822732 (CHEMBL4322496)
IC50
149±n/a nM
Citation
 Borsari, C; Rageot, D; Dall'Asen, A; Bohnacker, T; Melone, A; Sele, AM; Jackson, E; Langlois, JB; Beaufils, F; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. J Med Chem 62:8609-8630 (2019) [PubMed]  Article 
Target
Name:
Target of rapamycin complex subunit LST8
Synonyms:
G protein beta subunit-like | Gable | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8 | LST8_HUMAN | MLST8 | GBL | LST8
Type:
PROTEIN
Mol. Mass.:
35871.25
Organism:
Human
Description:
ChEMBL_118692
Residue:
326
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
  
Inhibitor
Name:
BDBM50505421
Synonyms:
CHEMBL4458426
Type:
Small organic molecule
Emp. Form.:
C19H24N6O2
Mol. Mass.:
368.44
SMILES:
[H][C@]12Cc3c(nc(nc3N3CCOC[C@@H]3C)-c3ccc(N)nc3)N1CCOC2 |r|
Structure:
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