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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50508106
Substrate
n/a
Meas. Tech.
ChEMBL_1832094 (CHEMBL4332102)
EC50
1360±n/a nM
Citation
 Choung, W; Jung, HJ; Yang, D; Nam, EH; Choi, H; Lee, BR; Park, M; Jang, SM; Lim, JS; Kim, WS; Kim, KH; Chin, J; Jung, K; Lee, G; Hong, E; Jang, TH; Myung, J; Kim, SH Identification of BR101549 as a lead candidate of non-TZD PPARĪ³ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. Bioorg Med Chem Lett 29:631-637 (2019) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Human
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50508106
Synonyms:
CHEMBL4517263
Type:
Small organic molecule
Emp. Form.:
C31H34N4O5
Mol. Mass.:
542.64
SMILES:
CCCCc1nc(C(C)C)c(CC(=O)OC2CC2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: