Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50508111
Substrate
n/a
Meas. Tech.
ChEMBL_1832093 (CHEMBL4332101)
IC50
1.5±n/a nM
Citation
 Choung, W; Jung, HJ; Yang, D; Nam, EH; Choi, H; Lee, BR; Park, M; Jang, SM; Lim, JS; Kim, WS; Kim, KH; Chin, J; Jung, K; Lee, G; Hong, E; Jang, TH; Myung, J; Kim, SH Identification of BR101549 as a lead candidate of non-TZD PPARĪ³ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. Bioorg Med Chem Lett 29:631-637 (2019) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
Angiotensin II AT1 | Angiotensin II type 1b (AT-1b) receptor | AT1 | Angiotensin II receptor | AT1BR | AT1AR | Type-1 angiotensin II receptor (AT1) | AGTR1_HUMAN | AGTR1 | AGTR1A | AGTR1B | AT2R1 | AT2R1B
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Human
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50508111
Synonyms:
CHEMBL4520827
Type:
Small organic molecule
Emp. Form.:
C27H33N7S
Mol. Mass.:
487.68
SMILES:
CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
Structure:
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