Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50508112
Substrate
n/a
Meas. Tech.
ChEMBL_1832102 (CHEMBL4332110)
IC50
>75000±n/a nM
Citation
 Choung, W; Jung, HJ; Yang, D; Nam, EH; Choi, H; Lee, BR; Park, M; Jang, SM; Lim, JS; Kim, WS; Kim, KH; Chin, J; Jung, K; Lee, G; Hong, E; Jang, TH; Myung, J; Kim, SH Identification of BR101549 as a lead candidate of non-TZD PPARĪ³ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. Bioorg Med Chem Lett 29:631-637 (2019) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
Peroxisome proliferator-activated receptor delta | PPAR delta | NUCI | Nuclear hormone receptor 1 | NUC1 | Nuclear receptor subfamily 1 group C member 2 | Peroxisome proliferator-activated receptor beta | PPAR-beta | PPARD_HUMAN | PPARD | NR1C2 | PPARB | Peroxisome proliferator-activated receptor
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Human
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50508112
Synonyms:
CHEMBL4546437
Type:
Small organic molecule
Emp. Form.:
C30H34N4O5
Mol. Mass.:
530.63
SMILES:
CCCCc1nc(C(C)C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1
Structure:
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