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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50062675
Substrate
n/a
Meas. Tech.
ChEMBL_4158 (CHEMBL619225)
IC50
160±n/a nM
Citation
 Hopper, AT; Witiak, DT; Ziemniak, J Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid. J Med Chem 41:420-7 (1998) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
LOX5_RAT | Alox5 | Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
78082.31
Organism:
Rat
Description:
ChEMBL_1432947
Residue:
673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50062675
Synonyms:
5-{4-[5-(4-Fluoro-benzyl)-thiophen-2-yl]-but-3-ynyl}-3,4-dihydroxy-5H-furan-2-one | CHEMBL132859
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Oc1oc(CCC#Cc2ccc(Cc3ccc(F)cc3)s2)c(O)c1O
Structure:
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