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Target
Acid-sensing ion channel 1/2
Ligand
BDBM50510034
Substrate
n/a
Meas. Tech.
ChEMBL_1840001 (CHEMBL4340216)
IC50
>30000±n/a nM
Citation
 Bencheva, LI; De Matteo, M; Ferrante, L; Ferrara, M; Prandi, A; Randazzo, P; Ronzoni, S; Sinisi, R; Seneci, P; Summa, V; Gallo, M; Veneziano, M; Cellucci, A; Mazzocchi, N; Menegon, A; Di Fabio, R Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS. ACS Med Chem Lett 10:627-632 (2019) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 1/2
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1840001
Components:
This complex has 2 components.
Component 1
Name:
Acid-sensing ion channel 1
Synonyms:
ASIC1_MOUSE | Asic1 | Accn2 | Asic | Bnac2 | Acid-sensing ion channel | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | Brain sodium channel 2
Type:
PROTEIN
Mol. Mass.:
59657.36
Organism:
Mouse
Description:
ChEMBL_119368
Residue:
526
Sequence:
MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
  
Component 2
Name:
Acid-sensing ion channel 2
Synonyms:
ASIC2_MOUSE | Asic2 | Accn1 | Bnac1 | Acid-sensing ion channel 2 | Amiloride-sensitive brain sodium channel | Amiloride-sensitive cation channel 1, neuronal | BNC1 | Brain sodium channel 1
Type:
PROTEIN
Mol. Mass.:
57721.82
Organism:
Mouse
Description:
ChEMBL_119368
Residue:
512
Sequence:
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC
  
Inhibitor
Name:
BDBM50510034
Synonyms:
CHEMBL4593063
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: