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Target
Neutrophil collagenase
Ligand
BDBM50064343
Substrate
n/a
Meas. Tech.
ChEMBL_105216 (CHEMBL713853)
Ki
531±n/a nM
Citation
 Cherney, RJ; Wang, L; Meyer, DT; Xue, CB; Wasserman, ZR; Hardman, KD; Welch, PK; Covington, MB; Copeland, RA; Arner, EC; DeGrado, WF; Decicco, CP Macrocyclic amino carboxylates as selective MMP-8 inhibitors. J Med Chem 41:1749-51 (1998) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
Matrix metalloproteinase-8 | MMP-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL | MMP8_HUMAN | MMP8 | CLG1
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Human
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50064343
Synonyms:
(3S,5R,13S)-13-Methylcarbamoyl-2,7-dioxo-3-phenethyl-1,4,8triaza-cyclotridecane-5-carboxylic acid | CHEMBL46183
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CNC(=O)[C@@H]1CCCCNC(=O)C[C@@H](N[C@@H](CCc2ccccc2)C(=O)N1)C(O)=O
Structure:
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