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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50103521
Substrate
n/a
Meas. Tech.
ChEMBL_1843860 (CHEMBL4344287)
IC50
1150±n/a nM
Citation
 Romero, FA; Jones, CT; Xu, Y; Fenaux, M; Halcomb, RL The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem 63:5031-5073 (2020) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Ppara | Nr1c1 | Ppar | Peroxisome Proliferator-Activated Receptor alpha
Type:
PROTEIN
Mol. Mass.:
52343.28
Organism:
Mouse
Description:
ChEMBL_572395
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50103521
Synonyms:
CHEBI:8228 | Actos | Duetact | Pioglitazone | US20240091210, Compound Pioglitazone
Type:
Small organic molecule
Emp. Form.:
C19H20N2O3S
Mol. Mass.:
356.12
SMILES:
CCc1ccc(nc1)CCOc2ccc(cc2)C[C@@H]3C(=O)NC(=O)S3
Structure:
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