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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50068074
Substrate
n/a
Meas. Tech.
ChEMBL_31336 (CHEMBL645542)
IC50
48±n/a nM
Citation
 Fresneau, P; Cussac, M; Morand, JM; Szymonski, B; Tranqui, D; Leclerc, G Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors. J Med Chem 41:4706-15 (1998) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
ALDR_BOVIN | AKR1B1 | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bovine
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50068074
Synonyms:
{5-[1-(3-Chloro-naphthalen-2-yl)-meth-(Z)-ylidene]-2,4-dioxo-thiazolidin-3-yl}-acetic acid | CHEMBL142001
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)CN1C(=O)S\C(=C/c2cc3ccccc3cc2Cl)C1=O
Structure:
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