Reaction Details
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Report a problem with these dataTarget
Alpha-2A adrenergic receptor
Ligand
BDBM50514727
Substrate
n/a
Meas. Tech.
ChEMBL_1858221 (CHEMBL4358950)
Ki
0.323594±n/a nM
Citation
Abás, S; Rodríguez-Arévalo, S; Bagán, A; Griñán-Ferré, C; Vasilopoulou, F; Brocos-Mosquera, I; Muguruza, C; Pérez, B; Molins, E; Luque, FJ; Pérez-Lozano, P; de Jonghe, S; Daelemans, D; Naesens, L; Brea, J; Loza, MI; Hernández-Hernández, E; García-Sevilla, JA; García-Fuster, MJ; Radan, M; Djikic, T; Nikolic, K; Pallàs, M; Callado, LF; Escolano, C Bicyclic α-Iminophosphonates as High Affinity Imidazoline I J Med Chem 63:3610-3633 (2020) [PubMed] Article More Info.:
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADRA2R | Adrenergic receptor alpha | ADRA2A | Adrenergic alpha2A | Alpha-2 adrenergic receptor subtype C10 | alpha-2A adrenergic receptor [Homo sapiens] | ADRAR | ADA2A_HUMAN | Alpha-2AAR | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Human
Description:
P08913
Residue:
465
Sequence:
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Inhibitor
Name:
BDBM50514727
Synonyms:
CHEMBL4483022
Type:
Small organic molecule
Emp. Form.:
C16H25N2O5P
Mol. Mass.:
356.36
SMILES:
CCOP(=O)(OCC)C1N=CC2C1C(=O)N(C1CCCCC1)C2=O |c:9|
Structure:
