Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM22774
Substrate
n/a
Meas. Tech.
ChEBML_91004
IC50
3000±n/a nM
Citation
 Huang, FC; Chan, WK; Moriarty, KJ; Zhang, DC; Chang, MN; He, W; Yu, KT; Zilberstein, A Novel cytokine release inhibitors. Part I: Triterpenes. Bioorg Med Chem Lett 8:1883-6 (1999) [PubMed]  Article 
Target
Name:
Caspase-1
Synonyms:
Caspase | Interleukin-1 beta-converting enzyme | Caspase 1 | Interleukin-1 beta convertase | ICE | CASP1_HUMAN | CASP1 | IL1BC | IL1BCE
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Human
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM22774
Synonyms:
1,4-Benzoquinone | benzoquinone | cid_4650 | CHEMBL8320 | cyclohexa-2,5-diene-1,4-dione | Benzil-related compound, 53
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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