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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50138819
Substrate
n/a
Meas. Tech.
ChEMBL_1866286 (CHEMBL4367261)
IC50
30±n/a nM
Citation
 Kumar, S; Waldo, JP; Jaipuri, FA; Marcinowicz, A; Van Allen, C; Adams, J; Kesharwani, T; Zhang, X; Metz, R; Oh, AJ; Harris, SF; Mautino, MR Discovery of Clinical Candidate (1 J Med Chem 62:6705-6733 (2019) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
IDO-1 | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase | I23O1_HUMAN | IDO1 | IDO | INDO | Indoleamine 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Human
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50138819
Synonyms:
CHEMBL3753837 | US10233190, Example 1357
Type:
Small organic molecule
Emp. Form.:
C18H21FN2O
Mol. Mass.:
300.16
SMILES:
OC(CC1c2c(cccc2F)-c2cncn12)C1CCCCC1
Structure:
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