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Target
Neutrophil elastase
Ligand
BDBM50071973
Substrate
n/a
Meas. Tech.
ChEBML_96776
IC50
60±n/a nM
Citation
 Llinàs-Brunet, M; Bailey, M; Déziel, R; Fazal, G; Gorys, V; Goulet, S; Halmos, T; Maurice, R; Poirier, M; Poupart, MA; Rancourt, J; Thibeault, D; Wernic, D; Lamarre, D Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease. Bioorg Med Chem Lett 8:2719-24 (1999) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin | Leukocyte elastase | ELNE_HUMAN | ELANE | ELA2
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Human
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50071973
Synonyms:
(S)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)-N-((1S,2S)-2-methyl-1-{(S)-2-methyl-1-[2-((S)-3,3,4,4,4-pentafluoro-2-oxo-1-propyl-butylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-butyl)-succinamic acid | CHEMBL2370192
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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