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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50072687
Substrate
n/a
Meas. Tech.
ChEMBL_216274 (CHEMBL819881)
Ki
30±n/a nM
Citation
 Wischnat, R; Martin, R; Takayama, S; Wong, CH Chemoenzymatic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors. Bioorg Med Chem Lett 8:3353-8 (1999) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50072687
Synonyms:
(S)-2-Amino-3-hydroxy-N-(3,4,5-trihydroxy-2-hydroxymethyl-6-methyl-piperidin-2-ylmethyl)-propionamide | CHEMBL539176
Type:
Small organic molecule
Emp. Form.:
C11H23N3O6
Mol. Mass.:
293.3168
SMILES:
CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O
Structure:
Search PDB for entries with ligand similarity: