Reaction Details Report a problem with these data
Target
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Ligand
BDBM50182487
Substrate
n/a
Meas. Tech.
ChEMBL_1897470 (CHEMBL4399505)
IC50
4000±n/a nM
Citation
 Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett 10:1154-1158 (2019) [PubMed]  Article 
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Synonyms:
Medulla oblongata-derived protein | Protein Mob | Sphingomyelin synthase 1 | Transmembrane protein 23 | SMS1_HUMAN | SGMS1 | MOB | SMS1 | TMEM23
Type:
PROTEIN
Mol. Mass.:
48630.99
Organism:
Human
Description:
ChEMBL_109868
Residue:
413
Sequence:
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
  
Inhibitor
Name:
BDBM50182487
Synonyms:
Malabaricone A
Type:
Small organic molecule
Emp. Form.:
C21H26O3
Mol. Mass.:
326.19
SMILES:
Oc1cccc(O)c1C(=O)CCCCCCCCc1ccccc1
Structure:
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