Reaction Details
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Phosphatidylcholine:ceramide cholinephosphotransferase 2
Ligand
BDBM50242188
Substrate
n/a
Meas. Tech.
ChEMBL_1897469 (CHEMBL4399504)
IC50
1500±n/a nM
Citation
Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett 10:1154-1158 (2019) [PubMed] Article More Info.:
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Synonyms:
Sphingomyelin synthase 2 | SMS2_HUMAN | SGMS2 | SMS2
Type:
PROTEIN
Mol. Mass.:
42294.80
Organism:
Human
Description:
ChEMBL_108027
Residue:
365
Sequence:
MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST
Inhibitor
Name:
BDBM50242188
Synonyms:
6-{8(Z)-pentadecenyl}salicylic acid | Anacardic acid 8'Z-monoene | 6-[8'(Z)-pentadecenyl]salicylic acid | 6-[8(Z)-pentadecatrienyl]salicylic acid | 6[8'(Z )-pentadecenyl]salicylic acid | 6-(8'Z-pentadecenyl)-salicylicacid | CHEMBL445177 | Ginkgolic acid C15:1 (1)
Type:
Small organic molecule
Emp. Form.:
C22H34O3
Mol. Mass.:
346.25
SMILES:
CCCCCC\C=C/CCCCCCCc1cccc(O)c1C(O)=O
Structure:
