Reaction Details Report a problem with these data
Target
Sodium/bile acid cotransporter
Ligand
BDBM50386790
Substrate
n/a
Meas. Tech.
ChEMBL_1897793 (CHEMBL4399828)
IC50
2000±n/a nM
Citation
 Zhao, S; Zhen, Y; Fu, L; Gao, F; Zhou, X; Huang, S; Zhang, L Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Sodium/bile acid cotransporter
Synonyms:
NTCP_HUMAN | SLC10A1 | NTCP | Bile acid transporter
Type:
PROTEIN
Mol. Mass.:
38131.81
Organism:
Human
Description:
ChEMBL_838517
Residue:
349
Sequence:
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
  
Inhibitor
Name:
BDBM50386790
Synonyms:
CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US11905230, Example TAK-875
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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