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Target
Retinoic acid receptor gamma
Ligand
BDBM50526312
Substrate
n/a
Meas. Tech.
ChEMBL_1899800 (CHEMBL4401915)
EC50
7.3±n/a nM
Citation
 Goncalves, MB; Clarke, E; Jarvis, CI; Barret Kalindjian, S; Pitcher, T; Grist, J; Hobbs, C; Carlstedt, T; Jack, J; Brown, JT; Mills, M; Mumford, P; Borthwick, AD; Corcoran, JPT Discovery and lead optimisation of a potent, selective and orally bioavailable RAR? agonist for the potential treatment of nerve injury. Bioorg Med Chem Lett 29:995-1000 (2019) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
Nr1b3 | RARG_MOUSE | Rarg
Type:
PROTEIN
Mol. Mass.:
50896.02
Organism:
Mus musculus
Description:
ChEMBL_196161
Residue:
458
Sequence:
MATNKERLFAPGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGGQGKRGQSPQPDQGP
  
Inhibitor
Name:
BDBM50526312
Synonyms:
CHEMBL4449668 | US10752616, Code No. BHBA-007
Type:
Small organic molecule
Emp. Form.:
C19H13FN2O4
Mol. Mass.:
352.3159
SMILES:
Cc1ccc(C)c2oc(cc12)-c1nc(no1)-c1ccc(C(O)=O)c(F)c1
Structure:
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