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Target
Cyclin-dependent kinase 7
Ligand
BDBM50526803
Substrate
n/a
Meas. Tech.
ChEMBL_1901116 (CHEMBL4403338)
IC50
20±n/a nM
Citation
 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Recent advances in the development of cyclin-dependent kinase 7 inhibitors. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 7
Synonyms:
39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:
Enzyme Subunit
Mol. Mass.:
39047.01
Organism:
Human
Description:
n/a
Residue:
346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
  
Inhibitor
Name:
BDBM50526803
Synonyms:
CHEMBL4434871 | US10870651, Compound 101
Type:
Small organic molecule
Emp. Form.:
C34H38N8O3
Mol. Mass.:
606.7173
SMILES:
CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3cccc(NC(=O)c4ccc(NC(=O)C=C)cc4)c3)n[nH]c2C1(C)C)c1ccccc1 |r|
Structure:
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