Target
Cyclin-dependent kinase 9
Ligand
BDBM50139171
Substrate
n/a
Meas. Tech.
ChEMBL_1901122 (CHEMBL4403344)
IC50
4.0±n/a nM
Citation
 Teng, YLu, KZhang, QZhao, LHuang, YIngarra, AMGalons, HLi, TCui, SYu, POumata, N Recent advances in the development of cyclin-dependent kinase 7 inhibitors. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 9
Synonyms:
C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
42789.13
Organism:
Human
Description:
n/a
Residue:
372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
  
Inhibitor
Name:
BDBM50139171
Synonyms:
Dinaciclib | MK-7965 | SCH-727965 | US11643396, Example Dinaciclib | US20230416221, Compound Dinaciclib
Type:
Small organic molecule
Emp. Form.:
C21H28N6O2
Mol. Mass.:
396.486
SMILES:
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO |r|
Structure:
Search PDB for entries with ligand similarity: